TFC 007 |
| Katalog-Nr.GC50101 |
TFC-007, ein selektiver Hemmer der hÄmatopoetischen Prostaglandin-D-Synthase (H-PGDS), zeigt eine hohe HemmaktivitÄt gegen das H-PGDS-Enzym (IC50-Wert von 83 nM). TFC-007 kann zur Zusammensetzung des H-PGDS-Abbau-Induktors PROTAC(H-PGDS)-1 verwendet werden (TFC-007 bindet an H-PGDS und Pomalidomid bindet an Kleinhirn).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 927878-49-7
Sample solution is provided at 25 µL, 10mM.
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Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50 = 83 nM). Inhibits PGD2 production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.
Nabe et al (2011) Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. Prostaglandins Other Lipid Mediat. 95 27 PMID:21601002
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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