TH5427 |
| Katalog-Nr.GC64717 |
TH5427 ist ein vielversprechender, zielgerichteter Inhibitor, der zur weiteren Untersuchung der NUDT5-AktivitÄt und des ADP-Ribose-Metabolismus verwendet werden kann. TH5427 blockiert die Progestin-abhÄngige, PAR-abgeleitete Kern-ATP-Synthese und den anschließenden Chromatin-Umbau, die Genregulation und die Proliferation in Brustkrebszellen. NUDT5 wurde kÜrzlich als Rheostat der hormonabhÄngigen Genregulation und Proliferation in Brustkrebszellen identifiziert.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2253744-56-6
Sample solution is provided at 25 µL, 10mM.
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TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells[1].
[1]. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250.
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