THAL-SNS-032 |
| Katalog-Nr.GC65346 |
THAL-SNS-032 ist ein selektiver CDK9-abbauender PROTAC, der aus einem CDK-bindenden SNS-032-Liganden besteht, der mit einem Thalidomid-Derivat verknÜpft ist, das die E3-Ubiquitin-Ligase Cereblon (CRBN) bindet.
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Cas No.: 2139287-33-3
Sample solution is provided at 25 µL, 10mM.
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THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].
THAL-SNS-032 selectively induces degradation of CDK9[1].THAL-SNS-032 diminishes elongating polymerase II[1].THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1].
[1]. Olson CM，et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170.
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