Thalidomide-NH-C2-PEG3-OH |
| Katalog-Nr.GC67504 |
Thalidomide-NH-C2-PEG3-OH ist ein E3-Ligase-Ligand-Linker-Konjugat, das Cereblon-Liganden auf Thalidomid-Basis und einen Linker enthält, der für den PROTAC BCL-XL-Abbauer XZ739 verwendet wird.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2140807-23-2
Sample solution is provided at 25 µL, 10mM.
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Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].
XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].
[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.
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