Thalidomide-Piperazine-Piperidine hydrochloride |
| Katalog-Nr.GC64640 |
Thalidomid-Piperazin-Piperidin-Hydrochlorid ist ein synthetisiertes E3-Ligase-Ligand-Linker-Konjugat. Thalidomid-Piperazin-Piperidin-Hydrochlorid enthÄlt den auf Thalidomid basierenden Cereblon-Liganden und einen Linker, der in der PROTAC-Technologie verwendet wird.
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Cas No.: 2599846-44-1
Sample solution is provided at 25 µL, 10mM.
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Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
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