Thanatin TFA |
| Katalog-Nr.GC72287 |
Thanatin TFA ist ein induzierbares kationisches antimikrobielles Peptid.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Thanatin TFA is strongly cationic (pI of 10.48) and contains a distinct short eight-residue basic loop created through a disulfide bond formation between residues Cys11 and Cys18 at the C-terminus. [1].
Thanatin TFA exhibits potent inhibitory effect on the growth of all New Delhi metallo-β-lactamase-1 (NDM-1)-producing E. coli and K. pneumoniae strains at 0.4-3.2 μM of the minimum inhibitory concentration (MIC) values[2].
Thanatin (1, 3, 6 mg/kg; ip; at 1 and 6 h) TFA protects mice infected with NDM-1-producing E. coli[2].
References:
[1]. Rachita Dash, et al. Thanatin: An Emerging Host Defense Antimicrobial Peptide with Multiple Modes of Action. Int J Mol Sci. 2021 Feb 3;22(4):1522.
[2]. Bo Ma, et al. The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase. Nat Commun. 2019 Aug 6;10(1):3517.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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