THZ-P1-2 |
| Katalog-Nr.GC39823 |
THZ-P1-2 ist ein erstklassiger und selektiver PI5P4K-Inhibitor mit einem IC50-Wert von 190 nM fÜr PI5P4Kα. THZ-P1-2 zielt kovalent auf Cysteine auf einer ungeordneten Schleife in PI5P4Kα/β/γ. THZ-P1-2 verursacht eine StÖrung der Autophagie und reguliert die TFEB-Signalgebung hoch. THZ-P1-2 zeigt AntikrebsaktivitÄt in LeukÄmie-Zelllinien.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2058075-45-7
Sample solution is provided at 25 µL, 10mM.
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THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines[1].
[1]. Sivakumaren SC, et al. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol. 2020;27(5):525‐537.e6.
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