TNP-ATP (sodium salt) |
| Katalog-Nr.GC90884 |
Ein Derivat von ATP und ein Antagonist der purinergen P2Y1, P2X3 und P2X2/3-Rezeptoren.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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TNP-ATP is a derivative of ATP and an antagonist of the purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50s = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing the human receptors).1 It is selective for these receptors over the purinergic P2X2, P2X4, and P2X7 receptors (IC50s = 2, 15.2, and >30 µM, respectively, in HEK293 cells expressing the human receptors). TNP-ATP decreases acetic acid-induced calcium flux in 1321N1 cells expressing the P2X3 and P2X2/3 receptors (IC50s = 100 and 62 nM, respectively).2 It reduces acetic acid-induced writhing in a mouse model of visceral pain (ED50 = 6.35 µmol/kg). It displays excitation/emission maxima of 403 and 547 nm, respectively, and its relative fluorescence increases four-fold when bound to insulin-degrading enzyme (IDE) with an emission maximum of 538 nm.3
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