Tosyl Phenylalanyl Chloromethyl Ketone (Synonyms: Nα-Tosyl-L-Phenylalanine Chloromethyl Ketone, TPCK) |
| Katalog-Nr.GC45066 |
Tosyl-Phenylalanyl-Chloromethyl-Keton (L-1-Tosylamido-2-Phenylethyl-Chloromethyl-Keton; L-Tosyl-Phenylalanyl-Chloromethyl-Keton) ist ein potenter Serinprotease-Inhibitor, der mit dem Retinoblastoma-Protein (RB)-bindenden Kern des HPV-18-E7-Proteins reagiert und abschafft seine RB-BindungsfÄhigkeit.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 402-71-1
Sample solution is provided at 25 µL, 10mM.
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Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis. It can disrupt PDK1 signaling to the AGC kinases, Akt, S6K1, and RSK, as well as MSK1 and MSK2. TPCK also inhibits superoxide production and suppresses neutrophil respiratory burst.
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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