TR antagonist 1 |
| Katalog-Nr.GC31402 |
TR-Antagonist 1 ist ein hochaffiner SchilddrÜsenhormonrezeptor (TR)-Antagonist mit IC50-Werten von 36 und 22 nM fÜr TRα bzw. TRβ.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 500794-88-7
Sample solution is provided at 25 µL, 10mM.
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TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
TR antagonist 1 displays high affinity for both thyroid hormone TRα and TRβ (IC50=36 and 22 nM, respectively). TR antagonist 1 acts as a full antagonist in the TRAFR cell assay and the IC50 32 nM for both TRAFα1 and TRAFβ1[1].
TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model[1].
[1]. Koehler K, et al. Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49(23):6635-7.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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