TRAF-STOP inhibitor 6877002 |
| Katalog-Nr.GC38868 |
TRAF-STOP-Inhibitor 6877002, ist ein selektiver Inhibitor der CD40-TRAF6-Wechselwirkung, Verbindung VII, zeigt eine Hemmung der NF-κB-Aktivierung in RAW-Zellen, extrahiert aus dem Patent WO2014033122A1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 433249-94-6
Sample solution is provided at 25 µL, 10mM.
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TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2].
[1]. Seijkens TTP, et al. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.
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