UC-514321 |
Katalog-Nr.GC39457 |
UC-514321, ein strukturelles Analogon von NSC370284 mit hÖherer AktivitÄt, zielt direkt auf STAT3/5 ab und unterdrÜckt die TET1-Expression, aber nicht TET2 oder TET3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 299420-83-0
Sample solution is provided at 25 µL, 10mM.
UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity[1].
[1]. Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099.
Average Rating: 5
(Based on Reviews and 3 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *