Urocortin (rat) (Synonyms: Urocortin (Rattus norvegicus); Rat urocortin;) |
Katalog-Nr.GC12802 |
Urocortin (Ratte) (Urocortin (Rattus norvegicus)) ist ein Neuropeptid und ein potenter endogener CRFR-Agonist mit Kis von 13 nM, 1,5 nM und 0,97 nM für humanes CRF1, Ratten-CRF2α bzw. Maus-CRF2β.
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Cas No.: 171543-83-2
Sample solution is provided at 25 µL, 10mM.
Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for hCRF1, rCRF2α and mCRF2β, respectively.
Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively[1].
Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior[2].
References:
[1]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.
[2]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.
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