Valategrast hydrochloride (Synonyms: R-411) |
| Katalog-Nr.GC64212 |
Valategrasthydrochlorid (R-411) ist ein potenter dualer Antagonist von Integrin α4β1 (VLA-4) und α4β7.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 828271-96-1
Sample solution is provided at 25 µL, 10mM.
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Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2].
Valategrast (hydrochloride) contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS)[2].
[1]. Woodside DG, et al. Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease. BioDrugs. 2008;22(2):85-100.
[2]. Halland N, et al. Small Macrocycles As Highly Active Integrin α2β1 Antagonists. ACS Med Chem Lett. 2014 Jan 10;5(2):193-8.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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