Verubecestat (MK-8931) Trifluoroacetate (Synonyms: MK-8931) |
Katalog-Nr.GC26035 |
Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2095432-65-6
Sample solution is provided at 25 µL, 10mM.
Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
Verubecestat(MK-8931) effectively reduces Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM[2].
Verubecestat(MK-8931) dramatically lowers CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. Due to the 20 h half-life of MK-8931 it is ideal for once-a-day dosing[2].
[1] Evin G, et al. BioDrugs. 2016, 30(3):173-94. [2] Yan R, et al. Transl Neurodegener. 2016, 5:13.
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *