WKYMVm (trifluoroacetate salt) (Synonyms: Trp-Lys-Tyr-Met-Val-D-Met)

WKYMVm is a synthetic peptide agonist of formyl peptide receptor 1 (FPR1) and FPR2, which was previously known as formyl peptide receptor-like 1 (FPRL1).^1,2,3 It induces calcium mobilization in ETFR rat basophilic leukemia cells transfected with FPR1 or FPR2 when used at a concentration of 0.1 nM.¹ WKYMVm stimulates chemotaxis of monocytes, dendritic cells, and natural killer (NK) cells, as well as induces superoxide production in monocytes and neutrophils, in vitro.³ In vivo, WKYMVm (8 mg/kg) reverses mucosal destruction, decreases in body weight, and colonic shortening in a mouse model of colitis induced by dextran sulfate (sodium salt) . Topical application of WKYMVm stimulates angiogenesis and accelerates re-epithelialization and granulation tissue formation in a rat model of diabetic cutaneous wounds.²

1.Le, Y., Gong, W., Li, B., et al.Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activationJ. Immunol.163(12)6777-6784(1999) 2.Kwon, Y.W., Heo, S.C., Jang, I.H., et al.Stimulation of cutaneous wound healing by an FPR2-specific peptide agonist WKYMVmWound Repair Regen.23(4)575-582(2015) 3.Kim, S.D., Kwon, S., Lee, S.K., et al.The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitisExp. Mol. Med.45(9)e40(2013)