XY 018 |
| Katalog-Nr.GC50389 |
XY 018 ist ein potenter ROR-γ-selektiver Antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1873358-87-2
Sample solution is provided at 25 µL, 10mM.
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RORγ antagonist (EC50 = 190 nM). Suppresses androgen receptor expression in prostate cancer cell lines. Also inhibits growth of tumors in androgen receptor-positive xenograft models.
Wang et al (2016) ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat.Med. 22 488 PMID:27019329 |Ndagi et al (2016) Re-emergence of an orphan therapeutic target for the treatment of resistant prostate cancer - a through conformational and binding analysis for RORγ protein. J.Biomol.Struct.Dyn. 36 1
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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