Zunsemetinib M-atropisomer (Synonyms: Zunsemetinib M-atropisomer; (M)-ATI-450; ATI-450 M-atropisomer; ATI-450; ATI450; ATI 450; CDD-450 M-atropisomer ; CDD 450; CDD450;) |
| Katalog-Nr.GB62211 |
Zunsemetinib M-atropisomer is the inactive isomer of Zunsemetinib.
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Cas No.: 1640282-44-5
Sample solution is provided at 25 µL, 10mM.
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Zunsemetinib M-atropisomer is the inactive isomer of Zunsemetinib. Zunsemetinib, also known as ATI-450 and CDD450, is the P-atropisomer and is a potent MK2 Inhibitor. ATI-450 binds with high affinity to the interface of the p38MAPK-MK2 complex and selectively inhibits p38MAPK-catalysed phosphorylation of MK2 which stabilises the inactive conformation of MK2, and subsequently reduces inflammatory cytokine levels. ATI-450 specifically blocks the downstream MK2-mediated inflammatory drive on the p38 pathway and may therefore avoid the tachyphylaxis associated with p38 inhibitors. Note CAS#1640282-42-3 is the active P-atropisomer. CAS# 1640282-44-5 is the inactive M-astropisomer.
Review for Zunsemetinib M-atropisomer
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for Zunsemetinib M-atropisomer
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