Dienamide A2 (Synonyms: (2E,4E)-N-Isobutyldodeca-2,4-dienamide) |
| Catalog No.GB40178 |
Dienamide A2 (24738-51-0) is an analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFα mRNA expression in human monocytes/macrophages via the CB2 receptor. Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively). It elevates intracellular Ca levels in CB2-positive but not in CB2-negative cells and this effect was blocked by SR144528. It significantly inhibits LPS-induced TNFα and IL-1β expression in a CB2-independent manner.
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Cas No.: 24738-51-0
Sample solution is provided at 25 µL, 10mM.
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Dienamide A2 (24738-51-0) is an analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFα mRNA expression in human monocytes/macrophages via the CB2 receptor. Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively). It elevates intracellular Ca levels in CB2-positive but not in CB2-negative cells and this effect was blocked by SR144528. It significantly inhibits LPS-induced TNFα and IL-1β expression in a CB2-independent manner.
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