Dolastatin 15 (trifluoroacetate salt) |
| Catalog No.GC90366 |
A peptide with anticancer activity
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Dolastatin 15 is a peptide that has been found in D. auricularia and has anticancer activity.1,2,3 It induces cell cycle arrest at the G2/M phase and inhibits proliferation of JVM-2 and EHEB human B cell leukemia cells when used at a concentration of 1 nM.1 Dolastatin 15 also inhibits proliferation of RPMI-8826, U266, and IM-9 human multiple myeloma cells (IC50s = 0.5-1 nM), as well as a panel of colon and ovarian cancer cell lines (IC50s = 0.031-1.8 nM).2,3 It reduces tumor growth in a CH1 mouse xenograft model when administered at a dose of 5.25 mg/kg per day.3
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