DTPD-Q (Synonyms: 2,5-Bis(o-tolylamino)cyclohexa-2,5-diene-1,4-dione,DTPD-quinone) |
| Catalog No.GC91590 |
DTPD-Q is an oxidized derivative of the antioxidant and methylphenyl substituted p-phenylenediamine DTPD.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 252950-56-4
Sample solution is provided at 25 µL, 10mM.
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DTPD-Q is an oxidized derivative of the antioxidant and methylphenyl substituted p-phenylenediamine DTPD.1 It is an inhibitor of dynamin 1 (IC50 = 273 µM) and reduces clathrin-mediated endocytosis in serum-starved U2OS cells (IC50 = 120 µM). DTPD-Q is less toxic to the aquatic bacterium V. fischeri than DTPD (EC50 = 1.98 mg/L).2 It increases intestinal permeability of, and production of reactive oxygen species (ROS) in, C. elegans when used at concentrations of 1 or 10 µg/ml.3 DTPD-Q has been found in roadway runoff water and roadside soils, indoor dust, as well as consumer products made from recycled tire rubber.4,5,6
References:
[1].MacGregor, K.A., Abdel-Hamid, M.K., Odell, L.R., et al.Development of quinone analogues as dynamin GTPase inhibitorsEur. J. Med. Chem.85191-206(2014).
[2].Wang, W., Chen, Y., Fang, J., et al.Toxicity of substituted p-phenylenediamine antioxidants and their derived novel quinones on aquatic bacterium: Acute effects and mechanistic insightsJ. Hazard. Mater.469:133900(2024).
[3].Wang, Y., Liang, G., Chao, J., et al.Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegansSci. Total Environ.927172306(2024).
[4].Cao, G., Wang, W., Zhang, J., et al.New evidence of rubber-derived quinones in water, air, and soilEnviron. Sci. Technol.56(7)4142-4150(2022).
[5].Zhu, J., Guo, R., Jiang, S., et al.Occurrence of p-phenylenediamine antioxidants (PPDs) and PPDs-derived quinones in indoor dustSci. Total Environ.912169325(2024).
[6].Zhao, H.N., Hu, X., Gonzalez, M., et al.Screening p-phenylenediamine antioxidants, their transformation products, and industrial chemical additives in crumb rubber and elastomeric consumer productsEnviron. Sci. Technol.57(7)2779-2791(2023).
| Cas No. | 252950-56-4 | SDF | |
| Synonyms | 2,5-Bis(o-tolylamino)cyclohexa-2,5-diene-1,4-dione,DTPD-quinone | ||
| Formula | C20H18N2O2 | M.Wt | 318.4 |
| Solubility | DMSO: Slightly soluble: 0.1-1mg/ml,Ethanol: Slightly soluble: 0.1-1mg/ml,PBS (pH 7.2): Slightly soluble: 0.1-1mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.1407 mL | 15.7035 mL | 31.407 mL |
| 5 mM | 0.6281 mL | 3.1407 mL | 6.2814 mL |
| 10 mM | 0.3141 mL | 1.5704 mL | 3.1407 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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