Enoticumab |
| Catalog No.GC72467 |
Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1192578-27-0
Sample solution is provided at 25 µL, 10mM.
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Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively.
References:
[1]. Kuhnert F, Chen G, Thurston G. Potent anti-tumor activity of blocking stromal Dll4 in ovarian xenograft models[J]. Cancer Research, 2013, 73(8_Supplement): 5091-5091.
Review for Enoticumab
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for Enoticumab
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