Flavokawain 1i |
| Catalog No.GC91152 |
A flavokawain derivative with anticancer and antiviral activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1098176-51-2
Sample solution is provided at 25 µL, 10mM.
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Flavokawain 1i is a derivative of the chalcones flavokawain A , flavokawain B , and flavokawain C and has anticancer and antiviral activities.1,2 It inhibits the proliferation of gefitinib-resistant H1975 non-small cell lung cancer (NSCLC) cells by 36%, as well as decreases protein levels of the heat shock protein 90 (Hsp90) client proteins EGFR, c-Met, HER2, Akt, and cyclin-dependent kinase 4 (Cdk4) and increases protein levels of Hsp70, markers of Hsp90 inhibition, when used at a concentration of 30 µM.1 Intramuscular administration of flavokawain 1i reduces viral titers in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV).2
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