Forodesine (hydrochloride) |
| Catalog No.GC91210 |
A nucleoside derivative and PNP inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Forodesine is a purine nucleoside derivative and purine nucleoside phosphorylase (PNP) inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively).1 It inhibits ptohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC50s = <0.1-0.38 µM) in the presence, but not absence, of 2’-deoxyguanosine . Forodesine inhibits the proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells.2 In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).1
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