13,14-dihydro-15-keto Prostaglandin E1-d4 (Synonyms: 13,14dh15k PGE1d4)

13,14-dihydro-15-keto Prostaglandin E₁-d₄ (13,14-dh-15-k PGE₁-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-k PGE₁ by GC- or LC-mass spectrometry. 13,14-dh-15-k PGE₁ is a metabolite of PGE₁ with much reduced biological activity.^1,2,3 Steady state plasma concentrations are about 10 pg/ml.¹ 13,14-dh-15-k PGE₁ is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC₅₀ values of 54 and 200 µM, respectively, compared to PGE₁ which has an IC₅₀ value of 40 nM.⁴

1.Leonhardt, A., Krauss, M., Gieler, U., et al.In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitisBr. J. Dermatol.136(3)337-340(1997) 2.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971) 3.Peskar, B.A., Cawello, W., Rogatti, W., et al.On the metabolism of prostaglandin E1 administered intravenously to human volunteersJournal of Physiology and Pharmacology42327-331(1991) 4.Kobzar, G., Mardla, V., JÄrving, I., et al.Antiaggregating potency of E-type prostaglandins in human and rabbit plateletsProceedings of the Estonian Academy of Sciences.Chemistry40179-180(1991)