(±)8(9)-EET-d11 (Synonyms: (±)8,9-EET-d11, (±)8,9-EpETrE-d11)

(±)8(9)-EET-d₁₁ contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)8(9)-EET by GC- or LC-mass spectrometry (MS). (±)8(9)-EET is biosynthesized from arachidonic acid in rat and rabbit liver microsomes by CYP450.^1,2 (±)8(9)-EET is a major P450 metabolite in the renal cortex.³ (±)8(9)-EET reduces GFR through cyclooxygenase-dependent preglomerular vasoconstriction.⁴

1.Chacos, N., Falck, J.R., Wixtrom, C., et al.Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acidBiochem. Biophys. Res. Commun.104(3)916-922(1982) 2.Oliw, E.H., Guengerich, F.P., and Oates, J.A.Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediatesJ. Biol. Chem.257(7)3771-3781(1982) 3.Zhang, J.Y., Prakash, C., Yamashita, K., et al.Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenaseBiochem. Biophys. Res. Commun.183(1)138-143(1992) 4.Katoh, T., Takahashi, K., Capdevila, J., et al.Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidneyAm. J. Physiol.261(4 Pt 2)F578-F586(1991)