(1S)-CCR2 antagonist 1 |
| Catalog No.GC70349 |
(1S)-CCR2 antagonist 1 est un lévochiral de l'antagoniste 1 du ccr2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1683534-97-5
Sample solution is provided at 25 µL, 10mM.
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The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), Ki=2.4 nM; RT=714 min)[1].
References:
[1]. Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34.
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