3-Hydroxy Midostaurin-D5 (Synonyms: CGP52421-D5) |
| Catalog No.GC62178 |
La 3-hydroxy-midostaurine-D5 (CGP52421-D5) est une 3-hydroxy-midostaurine marquée au deutérium. La 3-hydroxy-midostaurine est un métabolite de PKC412, qui inhibe efficacement l'autophosphorylation de la tyrosine kinase-3 (FLT3) de type FMS avec des IC50 d'environ 132 nM et 9,8 μM dans le milieu de culture et le plasma, respectivement.
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Sample solution is provided at 25 µL, 10mM.
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3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].
[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108(10):3477-83.
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