5S(6R)-EET (Synonyms: 5S(6R)-EpETrE,5S(6R)-epoxy-8(Z),11(Z),14(Z)-ETrE,5S(6R)-epoxy-all-cis-8,11,14-Eicosatrienoic Acid,5S(6R)-Epoxyeicosatrienoic Acid,FA 20:4;O) |
| Catalog No.GC91696 |
5S(6R)-EET is an oxylipin.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 98103-47-0
Sample solution is provided at 25 µL, 10mM.
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5S(6R)-EET is an oxylipin. It depolarizes transepithelial voltage in isolated rabbit renal cortical collecting duct when applied to the luminal side at a concentration of 1 µM.[1] In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.[2]
References:
[1].Sakairi, Y., Jacobson, H.R., Noland, T.D., et al.5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesisAm. J. Physiol.268(5 Pt 2)F931-F939(1995).
[2].Rashid, M., Manivet, P., Nishio, H., et al.Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modelingLife Sci.73(2)193-207(2003).
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