A11 (trifluoroacetate salt) (Synonyms: CPP-EYVQTVKSSKG) |
Catalog No.GC91473 |
A11 est un peptide pénétrant dans les cellules composé du domaine de transduction de protéine Tat du VIH-1 lié à un peptide de 11 acides aminés correspondant aux résidus 20-30 de l'extrémité N-terminale d'annexine A1.
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Sample solution is provided at 25 µL, 10mM.
A11 is a cell-penetrating peptide composed of the HIV-1 Tat protein transduction domain linked to an 11-amino acid peptide corresponding to residues 20-30 of the annexin A1 N-terminus.1 It decreases annexin A1 binding to Eph receptor tyrosine kinase A2 (EphA2) and increases EphA2 ubiquitination in HK1 nasopharyngeal carcinoma (NPC) cells. A11 (10 µM) inhibits HK1 and 5-8F NPC cell proliferation, migration, and invasion. In vivo, A11 reduces tumor volume in 5-8F and HK1 NPC mouse xenograft models.
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