ACT-389949 |
| Catalog No.GC60564 |
ACT-389949 est un premier de sa catégorie, puissant et sélectif, et agoniste du récepteur formyl peptide de type 2 (FPR2)/récepteur de la lipoxine A4 (ALX), avec une CE50 de 3 nM pour l'internalisation de FPR2/ALX dans les monocytes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1258417-54-7
Sample solution is provided at 25 µL, 10mM.
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ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders[1][2].
ACT-389949 has well tolerated. Maximum concentrations are reached around 2 hours after dosing, with a mean terminal half-life of 29.3 hours[1]. Administration of ACT-389949 results in a dose-dependent, long-lasting internalization of FPR2/ALX into leukocytes[1].
[1]. Stalder AK,et al. Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. Br J Clin Pharmacol. 2017 Mar;83(3):476-486. [2]. Lind S, et al. Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949. Biochem Pharmacol. 2019 Aug;166:163-173.
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