ACTH (1-13) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) |
| Catalog No.GC90287 |
Un fragment peptidique de l'ACTH
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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ACTH (1-13) is a peptide fragment of adrenocorticotropic hormone , a peptide hormone found in the brain that is involved in the biological stress response.1 An acetylated form of ACTH (1-13), α-melanocyte stimulating hormone (α-MSH), is formed in the intermediate lobe of the pituitary gland by cleavage of ACTH (1-39), as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1,2 ACTH (1-13) is an agonist of melanocortin receptor 3 (MC3R) and MC4R, inducing cAMP production in vitro with EC50 values of 0.18 and 19 nM, respectively, which is similar in potency to that of α-MSH.3 It induces differentiation of melanocytes when used at concentrations ranging from 0.001 to 1,000 nM.4 ACTH (1-13) (40 and 400 pmol, i.c.v.) decreases food intake in broiler chicks.5
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