ACTH (1-17) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) |
| Catalog No.GC90299 |
Un fragment peptidique de l'ACTH
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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ACTH (1-17) is a peptide fragment of adrenocorticotropic hormone , a peptide hormone found in the brain that is involved in the biological stress response.1 It binds to melanocortin receptors (MCRs; Kis = 0.23, 14, 419, and 4,240 nM for MC1R, MC3R, MC4R, and MC5R, respectively).2 It is an agonist at MC1R, increasing adenylate cyclase activity with an EC50 value of 3.02 nM in HEK293 cells expressing MC1R.3 ACTH (1-17) (160 µg/kg, i.v.) increases mean arterial blood pressure (MAP) following bleeding-induced potension in a rat model of hemorrhagic shock 15-30 minutes after administration.4 It induces melanogenesis in a biphasic manner (EC50s = 0.0001 and 0.08 nM) and differentiation of melanocytes when used at concentrations ranging from 0.01 to 1,000 nM.3,5
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