AG 1478 hydrochloride |
| Catalog No.GC50013 |
Le chlorhydrate d'AG 1478 (chlorhydrate de Tyrphostin AG 1478) est un inhibiteur sélectif de la tyrosine kinase EGFR avec une IC50 de 3 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 170449-18-0
Sample solution is provided at 25 µL, 10mM.
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Potent and selective inhibitor of epidermal growth factor receptor kinase (IC50 values 3 nM for EGFR and > 100 μM for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC50 = 1 μM).
Eguchi et al (1998) Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J.Biol.Chem. 273 8890 PMID:9535870 |Han et al (1996) Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors. Cancer Res. 56 3859 PMID:8752145 |Puri and Salgia (2008) Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer. J.Carcinog. 7 9 PMID:19240370 |Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782 PMID:7892601
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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