Amastatin (hydrochloride) |
| Catalog No.GC42777 |
L'amastatine (chlorhydrate) est un inhibiteur compétitif de l'aminopeptidase (AP) à liaison lente et étroite avec des valeurs Ki de 0,26 nM, 30 nM, 52 nM pour l'Aeromonas aminopeptidase, la leucine aminopeptidase cytosolique, l'aminopeptidase microsomale.
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Cas No.: 100938-10-1
Sample solution is provided at 25 µL, 10mM.
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Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 µg/ml) but not of AP-B (arginine AP). It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 µM). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.
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