AMG 511 |
| Catalog No.GC39695 |
L'AMG 511 est un inhibiteur pan puissant et disponible par voie orale des PI3K de classe I, avec un Kis de 4 nM, 6 nM, 2 nM et 1 nM pour PI3Kα, β, δ et γ, respectivement. AMG 511 supprime de manière significative la signalisation PI3K indiquée par la diminution de p-Akt (Ser473). AMG 511 présente une activité antitumorale dans un modèle de xénogreffe de glioblastome de souris.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1253573-53-3
Sample solution is provided at 25 µL, 10mM.
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AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks, with Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease. AMG 511 exhibits anti-tumor activity in mouse glioblastoma xenograft model[1].
[1]. Mark H Norman, et al. Selective Class I Phosphoinositide 3-kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511. J Med Chem. 2012 Sep 13;55(17):7796-816.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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