Amino-PEG11-amine |
| Catalog No.GC63930 |
L'amino-PEG11-amine, un lieur PROTAC À base de PEG (12 unités) utilisé pour combiner deux ligands À base de monodiéthylstilbestrol (DES), fournit une stratégie alternative pour préparer des antagonistes ER plus sélectifs et actifs pour l'hormonothérapie du cancer du sein.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 479200-82-3
Sample solution is provided at 25 µL, 10mM.
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Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15.
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