Amino-PEG4-CH2COOH |
| Catalog No.GC65843 |
Amino-PEG4-CH2COOH est un lieur PROTAC À base de PEG qui peut être utilisé dans la synthèse des PROTAC. Amino-PEG4-CH2COOH est également un lieur PEG ADC À 4 unités non clivable utilisé dans la synthèse de conjugués anticorps-médicament (ADC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 195071-49-9
Sample solution is provided at 25 µL, 10mM.
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Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
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