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Amisulpride (Synonyms: DAN 2163)

Catalog No.GC12610

L'amisulpride est un antagoniste des récepteurs dopaminergiques D2/D3 avec un Kis de 2,8 et 3,2 nM pour la dopamine humaine D2 et D3, respectivement.

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Amisulpride Chemical Structure

Cas No.: 71675-85-9

Taille Prix Stock Qté
10mM (in 1mL DMSO)
36,00 $US
En stock
50mg
50,00 $US
En stock
100mg
60,00 $US
En stock
200mg
97,00 $US
En stock
500mg
168,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

Amisulpride is an atypical antagonist of dopamine D2/D3 receptor with Ki values of 2.8±0.4nM and 3.2±0.3nM for D2 and D3 receptor subtypes, respectively [1].

Amisulpride has shown high affinity to the cloned and stably transfected human dopamine D2 with Ki values of 2.8±0.4nM and 3.2±0.3nM for D2 and D3 receptor subtypes, respectively. Amisulpride has been reported to inhibit radioligand binding to native dopamine D2 receptor in membranes from the rat striatum with an IC50 value of 21nM. Besides, Amisulpride has been revealed to displace [3H]raclopride binding in vivo with an ED50 value of 17.3±1.86mg/kg in the rat limbic system. In addition, Amisulpride has been noted to inhibit quinpirole-induced [3H]thymidine with an IC50 value of 22±3nM [1].

References:
[1] Schoemaker H1, Claustre Y, Fage D, Rouquier L, Chergui K, Curet O, Oblin A, Gonon F, Carter C, Benavides J, Scatton B. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J Pharmacol Exp Ther. 1997 Jan;280(1):83-97.

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