Apoptolidin (Synonyms: Apoptolidin A) |
| Catalog No.GC42827 |
L'apoptolidine est un polykétide isolé de la bactérie Nocardiopsis. L'apoptolidine est un inhibiteur sélectif de l'ATPase F1FO mitochondriale. L'apoptolidine est un inducteur de l'apoptose et induit la mort cellulaire apoptotique dans les cellules transformées avec les oncogènes de l'adénovirus de type 12, y compris ElA (IC50 = 10-17 ng/ml) mais pas dans les cellules normales.
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Cas No.: 194874-06-1
Sample solution is provided at 25 µL, 10mM.
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Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria. It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 µM). Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells. It also has antibiotic and antifungal actions.
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