AT-121 |
| Catalog No.GC42865 |
L'AT-121 est un agoniste bifonctionnel de la nociception et des récepteurs opioÏdes mu, avec un Kis de 3,67 et 16,49 nM, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2099681-31-7
Sample solution is provided at 25 µL, 10mM.
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AT-121 is a dual μ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPγS binding to cell membranes expressing μ-opioid or nociceptin receptors (EC50s = 19.6 and 34.7 nM, respectively). AT-121 (0.003-0.03 mg/kg) decreases capsaicin-induced thermal allodynia without increasing scratching activity in rhesus monkeys in a dose-dependent manner. It lacks reinforcing effects, a marker of abuse potential, and reduces oxycodone, but not food pellet, reinforcement in a drug self-administration assay in rhesus monkeys when administered at doses ranging from 0.3 to 10 μg/kg per injection. AT-121 (0.01 or 0.03 mg/kg) does not induce hyperalgesia, a marker of tolerance development, in rhesus monkeys.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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