AT6 |
| Catalog No.GC33354 |
AT6 est un analogue PROTAC AT1, qui est un PROTAC connecté par des ligands pour von Hippel-Lindau et BRD4 avec une haute sélectivité au bromodomaine (Brd4).
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Cas No.: 2098836-50-9
Sample solution is provided at 25 µL, 10mM.
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AT6 is a PROTAC AT1 analogue, which is a highly selective bromodomain (Brd4) degrader.
PROTACs (proteolysis-targeting chimaeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase: PROTAC: target species and how this impacts target degradation selectivity remains elusive. The ligand folds into itself to allow formation of specific intermolecular interactions in the ternary complex. Isothermal titration calorimetry studies, supported by surface mutagenesis and proximity assays, are consistent with pronounced cooperative formation of ternary complexes with Brd4BD2. Structure-based-designed compound AT1 exhibits highly selective depletion of Brd4 in cells[1].
[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.
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