AUT1 |
| Catalog No.GC19480 |
AUT1 est un modulateur du canal Kv3 humain recombinant.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1311136-84-1
Sample solution is provided at 25 µL, 10mM.
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AUT1 (AUT-1) is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively; displays approximately 10-fold lower potency for Kv3.3 channels, and does not interact with a wide range of ion channels, receptors, and transporters; increases hKv3.1b and hKv3.2a currents by 1049 ± 198% and 226 ± 39%, respectively, at 30 uM; rescue the fast firing capability of FS interneurons following a reduction in Kv3 channel availability, has the potential to rescue normal function and therapeutic benefit in disorders like schizophrenia or age-related cognitive decline.
Reference:
[2]. Brown MR, et al. J Neurophysiol. 2016 Jul 1;116(1):106-21.
[3]. Parekh PK, et al. Neuropsychopharmacology. 2018 Jan;43(2):435-444.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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