Autocamtide-2-related Inhibitory Peptide (trifluoroacetate salt) |
| Catalog No.GC91849 |
Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.[1],[2] It is nonphosphorylatable and selective for CaMKII over PKC, PKA and CaMKIV (IC50s > 10 μM).[1],[2] This compound is a useful tool for studying the physiological roles of CaMKII.[3]
References:
[1].Ishida, A., Kameshita, I., Okuno, S., et al.A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase IIBiochem. Biophys. Res. Commun.212(3)806-812(1995).
[2].Ishida, A., and Fujisawa, H.Stabilization of calmodulin-dependent protein kinase II through autoinhibitory domainJ. Biol. Chem.270(5)2163-2170(1995).
[3].Takasawa, S., Ishida, A., Nata, K., et al.Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilizationJ. Biol. Chem.270(51)30257-30259(1995).
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *