Boc-NH-PEG4-CH2COOH |
| Catalog No.GC64316 |
Boc-NH-PEG4-CH2COOH est un lieur ADC clivable utilisé comme lieur pour les conjugués anticorps-médicament (ADC). Boc-NH-PEG4-CH2COOH est également un lieur PROTAC À base de PEG qui peut être utilisé dans la synthèse des PROTAC.
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Cas No.: 876345-13-0
Sample solution is provided at 25 µL, 10mM.
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Boc-NH-PEG4-CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Maggie Lu, et al. Linker-drug and antibody-drug conjugate (adc) employing the same. EP3335734A1.
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