Boc-piperazine-benzoic acid |
| Catalog No.GC64096 |
L'acide boc-pipérazine-benzoÏque est un lieur PROTAC et peut être utilisé dans la synthèse des PROTAC, tels que le dégradeur des récepteurs androgènes (AR) PROTAC ARD-2128.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 162046-66-4
Sample solution is provided at 25 µL, 10mM.
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Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 [1].
ARD-2128 is a highly potent, orally bioavailable PROTAC androgen receptor (AR) degrader. ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. ARD-2128 has the potential for the research of the prostate cancer[1].
[1]. Han X, et al. Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer. J Med Chem. 2021;64(17):12831-12854.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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