Boc-trans-D-Hyp-OMe |
Catalog No.GC64198 |
Boc-trans-D-Hyp-OMe est un lieur ADC non clivable utilisé dans la synthèse de conjugués anticorps-médicament (ADC). Boc-trans-D-Hyp-OMe est également un lieur PROTAC À base de chaÎne alkyle qui peut être utilisé dans la synthèse des PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 135042-17-0
Sample solution is provided at 25 µL, 10mM.
Boc-trans-D-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-trans-D-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Average Rating: 5
(Based on Reviews and 12 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *