BR351 precursor |
Catalog No.GC33365 |
Le précurseur du BR351 est un précurseur du BR351. BR351 est un inhibiteur de MMP pénétrant dans le cerveau avec des IC50 de 4, 2, 11, 50 nM pour MMP2, MMP8, MMP9 et MMP13, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 960113-89-7
Sample solution is provided at 25 µL, 10mM.
BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1]. Potential tools for the molecular imaging of activated MMPs with PET[2].
[1]. Wagner S, et al. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007 Nov 15;50(23):5752-64. [2]. Vazquez N, et al. Evaluation of [18 F]BR420 and [18 F]BR351 as radiotracers for MMP-9 imaging in colorectal cancer. J Labelled Comp Radiopharm. 2017 Jan;60(1):69-79.
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