BRD9539 |
| Catalog No.GC32988 |
BRD9539 est un inhibiteur de l'histone méthyltransférase G9a avec une IC50 de 6,3 μM. BRD9539 inhibe également l'activité de PRC2 et est inactif contre SUV39H1, NSD2 et DNMT1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1374601-41-8
Sample solution is provided at 25 µL, 10mM.
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BRD9539 inhibits G9a activity with an IC50 of 6.3 μM, inhibits PRC2 activity with a similar IC50.target: G9a, PRC2;IC50: 6.3 μM ( G9a ), 6.3 uM ( PRC2 ); BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration.
[1]. Yuan Y et al. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol. 2012 Jul 20;7(7):1152-7.
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