Brevetoxin B (Synonyms: Brevetoxin 2, BTX-B, GbTx-2, PbTx-2) |
Catalog No.GC42976 |
Brevetoxin B (Brevetoxin-2; PbTx-2) est une neurotoxine polycétide produite par les espèces de Karenia et d'autres dinoflagellés.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 79580-28-2
Sample solution is provided at 25 µL, 10mM.
Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.
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